As summer unfolds in the year 2023, people will contend with not only scorching temperatures but also the constant annoyance of mosquitoes buzzing around and biting at every opportunity. The combination of high temperatures and factors such as food spoilage creates an ideal breeding ground for mosquitoes, making them a prominent threat during the summer … Read more
Safe and effective systemic delivery of mRNA to specific organs and cells in vivo remains a major challenge in the development of mRNA-based therapies. Currently, the application of mRNA-based technologies is largely limited to liver diseases because of the lack of specific and effective extrahepatic systemic mRNA delivery systems in vivo. Now, a team of researchers … Read more
The field of biopharmaceuticals is playing an increasingly pivotal role in medical treatment but is encountering several challenges. One pressing issue is the short half-life of many biopharmaceutical products, which leads to rapid degradation and clearance from the patient’s body, necessitating frequent dosing. In this article, we explore how half-life extension strategies in drug development … Read more
Therapeutic antibodies, engineered through biotechnology, represent a specialized class of antibodies used in disease treatment. These antibodies are designed to target specific disease markers, such as malignant tumors, autoimmune disorders, and infectious diseases. Compared to traditional antibody therapies, therapeutic antibodies offer higher specificity and fewer side effects. In the realm of immunotherapy, antibody-dependent cell-mediated cytotoxicity … Read more
There is mounting proof that the enzyme mitogen-activated protein kinase 4 (MAPK4), which is also known as extracellular-regulated kinase 4 (ERK4), contributes to tumor expansion and treatment resistance. Researchers from Baylor College of Medicine and other institutions recently published their findings that MAPK4 appears to play an important role in the development of triple negative breast … Read more